The correct option is D Provide them an antithyroid substance like thiourea.
During metamorphosis, a tadpole is changed into the frog due to the over secretion of thyroxine hormone. But in the presence of antithyroid substance like thiourea, metamorphosis is stopped. The antithyroid drug acts antagonistically upon over reactive thyroid gland and reduces the secretion of thyroxine hormone which prevents the metamorphosis in the frog.