Active transport mechanisms require the use of cellular energy, primarily in the form of adenosine triphosphate (ATP).
If a substance must enter the cell against a concentration gradient, that is, if the concentration of the substance inside the cell must be higher than that in the extracellular fluid, the cell must expend energy to move the substance.
Several active transport mechanisms move low molecular weight substances such as Ions passing through the membrane.
In short, cells must expend energy to move substances electrochemically or against a concentration gradient.