The interstitium is fluid and the tissues that connect it that are present throughout the body, including just below the skin and in the digestive, respiratory, and urinary systems.
It is not merely a passive conduit system for the flux of fluid and solutes.
Salt also referred to as sodium chloride, is an ionic substance with the chemical formula NaCl.
The ascending portion of the vasa recta returns NaCl to the interstitium.
NaCl and urea are the main culprits of this gradient.
The ascending limb of Henle's loop, which is switched for the descending limb of the vasa recta, transports NaCl.
The ascent of the vasa recta returns NaCl to the interstitium.