Question

If GABA is released at synapse, then what will happen?

• A. Depolarization of neuron
• B. Repolarization of neuron
• C. Hyperpolarization of neuron
• D. No effect

Answer 1

Answer: (C)

Hyperpolarization of neuron

The neurotransmitter at inhibitory synapses hyperpolarizes the postsynaptic membrane. For example, gamma-aminobutyric acid (GABA). Binding of GABA to the receptors increases the influx of chloride (Cl) ions into the postsynaptic cell and efflux potassium ($K^{+}$) ions decreasing its membrane potential and thus inhibiting it.