If the CO2 level increases in the blood, it favours ______
Unloading of O2 from the blood
As the pCO2 in the blood increases, the affinity of oxygen for Hb is reduced. This can be seen in the shift of the O2 - Hb dissociation curve to the right (Bohr shift). The chief consequence of the shift is that the pO2 needed to produce any given saturation of Hb must be greater in the presence of increased CO2. In addition, in rapidly metabolizing tissues, there will be an increased unloading of oxygen.