In a nucleus, the number of ribonucleoside triphosphates is 10 times the number of deoxyribonucleoside triphosphates, but only deoxyribonucleotides are added during the DNA replication. Suggest a mechanism.

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Solution

$D N A d e p e n d e n t D N A p o l y m e r a s e :$

DNA dependent DNA polymerase cannot bind to the ribonucleotides, because it cannot accommodate the 2’- OH of the ribose sugar in the active site. So it adds only deoxyribonucleotides and are specific to dNTPs.

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Standard IX Biology

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In a nucleus, the number of ribonucleoside triphosphates is 10 times the number of deoxyribonucleoside triphosphates, but only deoxyribonucleotides are added during the DNA replication. Suggest a mechanism.

DNA dependent DNA polymerase: DNA dependent DNA polymerase cannot bind to the ribonucleotides, because it cannot accommodate the 2’- OH of the ribose sugar in the active site. So it adds only deoxyribonucleotides and are specific to dNTPs.

$D N A d e p e n d e n t D N A p o l y m e r a s e :$

DNA dependent DNA polymerase cannot bind to the ribonucleotides, because it cannot accommodate the 2’- OH of the ribose sugar in the active site. So it adds only deoxyribonucleotides and are specific to dNTPs.