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Question
In alpha thalassemia, the gene HBA1 is located on this chromosome.
In alpha thalassemia, the gene HBA1 is located on this chromosome.
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Solution
The correct option is D 16
The human alpha globin gene cluster is located on chromosome 16. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemia results from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1.
The human alpha globin gene cluster is located on chromosome 16. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemia results from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1.
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