Question

In controlling the synthesis and secretion of aldosterone which of the following factors is least important.

• A. Renin
• B. Angiotensin II
• C. Concentration of plasma Na${}^{+}$
• D. ACTH

Answer 1

The correct option is D ACTH

ACTH (Adrenocorticotropic hormone) is released from the anterior pituitary to act on the adrenal gland cortex. It stimulates the release of cortisol that further acts on gluconeogenesis and controlling stress. Aldosterone is released from the adrenal gland cortex to normalize the low blood pressure. It is released by the action of renin on the angiotensinogen. Angiotensinogen is converted to the Angiotensin-I and then to Angiotensin-II which then stimulates aldosterone secretion. The low concentration of Na${}^{+}$ is also responsible to trigger aldosterone release. It allows reabsorption of Na${}^{+}$ from the DCT of the nephron due to which the water is also absorbed.

Hence, the correct answer is 'ACTH'.