In the early experiments conducted by Walter Gilbert and Lydia Villa-Komaroff from Harvard University, the initial product obtained was not insulin but __________.

Proinsulin

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Preinsulin

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Penicillinase-proinsulin mixture

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Pre-proinsulin

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Solution

The correct option is C Penicillinase-proinsulin mixture
The cDNA made from proinsulin mRNA was used for gene transfer to produce insulin by Walter Gilbert and Lydia Villa-Komaroff from Harvard University. This gene got incorporated within the penicillinase gene site and the resultant product was a mixture of proinsulin and penicillinase. Gilbert used the enzyme trypsin to remove penicillinase portion of the mixture and got active insulin.

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