Inflammatory response in allergy is caused by the release of which one of the following by mast cells?
A
Histamines
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B
Antibodies
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C
Antigens
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D
None of the above
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Solution
The correct option is A Histamines The inflammatory response in allergies occurs when the tissues are injured by bacteria, trauma, toxins or by any other cause. The damaged cells (like mast cells) release chemicals including histamine, bradykinin and prostaglandins.
The underlying mechanism of allergic reaction involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamine Thus, the correct answer is the option (A),'Histamines'.