Question

Is allosteric inhibition only applicable in the lock and key mechanism?
Since the induced fit theory tells that the substrate can actually induce a change in the active site of the enzyme, hence even if the inibitor attaches itself to the enzyme, the substrate can attach to it (by changing the shape of the active site).

Answer 1

Allosteric inhibition is a class of enzyme inhibition in which an allosteric inhibitor inhibits enzyme by binding to the allosteric site of the enzyme. In the allosteric inhibition the conformation of active sites is changed so that substrate cannot combine with enzyme. Induced fit theory cannot be applicable in allosteric inhibiton. As the active site is completely distorted and inactivated the binding of the substrate molecule to the enzyme molecule cannot induce to modify shape of active properly to fit substrate. So the allosteric inhibition is not confined only to lock and key mechanism. So allosteric inhibition is applicable to mechanism other than lock and key