Leber's optic neuropathy is a mitochondrially inherited genetic disorder. What is probability of a couple having an affected son, if the father suffers from the disease and the mother does not?

0.25

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Solution

The correct option is B 0.0
In sperms, mitochondria are present in the middle piece which does not take part in fertilisation. This means, mitochondrial DNA is transmitted to the zygote only through the ovum. All mitochondrial DNA are maternally or cytoplasmically inherited. So, none of the sons would be affected as the mother is normal.

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