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Question

Match the antibody in Column I with the appropriate description in Column II

ColumnIColumnII1.lgAa.Maximum antigen binding capacity2.lgDb.Predominant immunoglobulin in bodily secretions3.lgEc.Physiological role unknown4.lgGd.Mediates allergic response5.lgMe.Mediates opsonization, can cross placenta


A

1-b, 2-c,3-d,4-e,5-a

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B

1-e, 2-c,3-d,4-b,5-a

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C

1-d, 2-c,3-a,4-b,5-e

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D

1-c, 2-d,3-a,4-b,5-e

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Solution

The correct option is C

1-b, 2-c,3-d,4-e,5-a


There are 5 classes of antibodies IgG, IgM, IgA, IgD and IgE. IgG is primary antibody produced by B cells. IgG mediates the phagocytosis of pathogens by binding to the receptors present on phagocytic cells with their Fc region. Thus the antibody enables phagocytic cells to recognize pathogens and mediates their phagocytosis in a process called opsonization. IgM is secreted as a pentamer i.e. five monomers joined by disulfide bonds. Each monomer has two antigen binding sites. As IgM is a pentamer, it has 10 antigen binding sites, maximum among the immunoglobulins. IgA is the predominant antibody found in bodily secretion like saliva , tears , etc, and is secreted as a dimer. IgE mediated allergic reactions by binding to mast cells and basophils . IgD constitutes merely 0.2% of the serum and its physiological role is still unknown


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