Question

Match the following
$\begin{array}{cc}ColumnI& ColumnII\\ \text{A. Humulin}& \text{i. Possesses 21 amino acids.}\\ \text{B. A-peptide}& \text{ii. Extra stretch present in pro-insulin.}\\ \text{C. B-peptide}& \text{iii. First genetically engineered hormone.}\\ \text{D. C-peptide}& \text{iv. Connects peptide chains.}\\ \text{E. Disulphide Bonds}& \text{v. Possesses 30 amino acids.}\end{array}$

• A. A-v, B-iv, C-iii, D-ii, E-i
• B. A- iii, B-i, C-v, D-ii, E-iv
• C. A-ii, B-iv,C-i,D-iii,E-v
• D. A-iv, B-iii, C-ii, D-i, E-v

Answer 1

The correct option is B A- iii, B-i, C-v, D-ii, E-iv

Humulin is the first genetically engineered hormone that was approved for human use. Insulin contains two polypeptide chains A peptide and B peptide. The 'A' peptide is made of 21 amino acids while the 'B' peptide is made of 30 amino acids. Insulin contains three disulphide bonds- two between A and B peptides and one within the A peptide. The C - peptide is present in pro-insulin connecting the A and B peptides. This is cleaved to form active insulin.