Question

Maturation of genetically engineered proinsulin into insulin

• A. Joining of C-peptide
• B. Removal of C-peptide
• C. Removal of Disulphide bridge
• D. All of the above

Answer 1

The correct option is B Removal of C-peptide

Preproinsulin is an inactive precursor to the active hormone insulin. Proinsulin is a single polypeptide chain made up of the two subunits, B and A of insulin joined by the C-peptide region. It is converted into proinsulin by peptidase enzyme. It removes peptide from its N-terminus. Hence, proinsulin is converted into the active insulin by removal of the C-peptide region.

Thus, the correct answer is option B.