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Question

Maturation of proinsulin into insulin takes place after:

A
Joining of C peptide
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B
Removal of C peptide
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C
Removal of sulphide bridge
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D
Addition of disulphide bridges
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Solution

The correct option is B Removal of C peptide
Maturation of proinsulin into insulin takes place after removal C peptide. Proinsulin is an inactive and single polypeptide chain of the B and A subunits joined by the C-peptide region. On maturation, the C-chain splits off, resulting in formation of insulin molecule.

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