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Question

Maturation of proinsulin into insulin takes place after

A
Addition of disulphide bridge
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B
Removal of disulphide bridge
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C
Joining of C peptide
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D
Removal of C peptide
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Solution

The correct option is D Removal of C peptide
Insulin hormone
In mammals including humans, insulin is synthesised as a prohormone known as proinsulin. It has to be processed to become a fully functional hormone.

Proinsulin to insulin
Immature proinsulin has C peptide present in between the A and B peptide chains. Immature proinsulin matures into functional insulin after the removal of the C peptide.

Pictorial representation






Final answer
(B) Removal of C peptide

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