Question

Mention the chemical change that proinsulin undergoes, to be able to act as mature insulin. [1]

Answer 1

Proinsulin is a polypetide that consists of the 'A' subunit and 'B' subunit of the insulin joined together by a 'C' chain. The proinsulin undergoes a chemical change where in the 'C' peptide is cleaved and removed. The removal is essential for proinsulin to be able to function as mature insulin. [1]