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Question

Mention the difference between hypothyroidism and hyperthyroidism.

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Solution

Differences between hypothyroidism and hyperthyroidism are as follows

HypothyroidismHyperthyroidismIt is the insufficient secretion ofThis sydrome arises as the body tissues and arethyroid hormones causing cretinismexposed to excessive levels of T3 and T4.in children and myxoedema in adultsThe main effects are due to increased metabolic rate.The gland enlarges and may develop single ormultiple hormone secreting cells such as in Gravesdisease and toxic nodular goitreCretinism is associated with theExophthalmic goitre (Graves disease) is the mostretarded mental and physicalcommon cause solid of thyrotoxicosis in adults. Itdevelopment. The child receiveaffects, women more commonly than men. High levelshormones form the mother beforeof thyroxine are secreted, which are not subjected tobirth, so appears normal at first, butthe normal secretion of TRH from the hypothalamuswithin a few weeks or months, itand TSH from the anterior pituitary.becomes evident that physical andmental development is retarded.Exophthalamus (protrusion of the eyeballs) due tothe deposition of excess fat and fibrous tissue behindSymptoms are disproportionatelythe eyes, is often present in Graves disease. In severeshort limbs, a large protrudingcases, the eyelids may not completely cover the eyestongue, coarse dry skin, poorduring blinking of the conjuctive and thus,abdominal muscle tone and anpredisposed to infectionumbilical harnia.Myxoedema (Gulls disease), thisToxic nodular goitre (Plaummers disease) is associatedconditions is common in adults andwith excess secretion of thyroxine leading to thefive times more common in femalesgeneral effects of increased metabolic rate.It results in an abnormally lowmetabolic rate and lack of responseto demand for increased energy, bymuscles, during exercise.Mental and physical processesbecome slower, skin become coarse,the hair lacks lustre, becomes brittleand tends to fall out.


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