A mixture is formed when atoms or molecules of the same or different particles combine with each other physically.
Milk is a mixture of cream and skimmed milk.
Its constituents can be separated using the technique of Centrifugation.
Centrifugation is a technique for separating suspended particles from liquids in which the mixture is rotated (or spun) at high speed in a centrifuge.
On rotation, the cream being lighter starts floating above the skimmed milk, which can be easily poured into another container to separate the constituents.