It is a series of symptoms caused by the human immunodeficiency virus (HIV).
A person is said to have AIDS when his/her immune system is too weak to fight off infection and there is the development of certain defining symptoms and illnesses.
This is the last stage of HIV.
No vaccination is possible for AIDS because:
HIV is found in semen, blood, breast milk, and vaginal fluids.
HIV virus is a retrovirus.
Retrovirus is a virus that has the capability of copying RNA into DNA.
The virus destroys a type of white blood cell in the immune system called a T-helper cell and makes copies of itself inside this cell.
No other virus discovered so far on Earth has this ability.
Therefore, it is the main limiting factor for the development of vaccination for AIDS.