Question

Normal cells have genes called ......(A)..... which are present in inactivated but under the certain condition like .....(B)...., they get transformation to .....(C).....

Here, A, B, and C refer to

• A. A- Cellular oncogenes, B- Mutation, C- Cancer causing oncogenes
• B. A- Proto-oncogenes, B- Mutation, C- Cancer causing genes
• C. A- Viral oncogenes, B- Mutation, C- Tumor causing genes
• D. None of the above

Answer 1

The correct option is B A- Proto-oncogenes, B- Mutation, C- Cancer causing genes

Proto-oncogene is a normal gene which, when altered by mutation, becomes an oncogene that can contribute to cancer. Proto-oncogenes may have many different functions in the cell. Some proto-oncogenes provide signals that lead to cell division. Other proto-oncogenes regulate programmed cell death (apoptosis). The defective versions of proto-oncogenes, known as oncogenes, can cause a cell to divide in an unregulated manner. This growth can occur in the absence of normal growth signals such as those provided by growth factors. A key feature of oncogene activity is that a single altered copy leads to unregulated growth.

So the correct option is 'A- Proto-oncogenes, B- Mutation, C- Cancer causing genes'