The correct option is D Beadle and Tatum
The one gene-one enzyme hypothesis was proposed by Beadle and Tatum. It suggests that a single gene produces a single enzyme, which later affects an individual step in a metabolic pathway. Beadle demonstrated that one gene in a fruit fly produces one enzyme which in turn controls a single chemical reaction. In this, each gene acts as a chemical molecule and has a particular function. Beadle and Tatum later confirmed this hypothesis using genetic and biochemical studies of the bread mold Neurospora crassa. Neurospora crassa to prove that in a multistep biochemical pathway, each step is controlled by different enzymes and each of these enzymes is encoded by a specific gene. This is called the one gene-one enzyme hypothesis.