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Question

One gene−one enzyme hypothesis was postulated by

A
R. Franklin
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B
Hershey and Chase
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C
A. Garrod
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D
Beadle and Tatum
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Solution

The correct option is D Beadle and Tatum
The one gene-one enzyme hypothesis was proposed by Beadle and Tatum. It suggests that a single gene produces a single enzyme, which later affects an individual step in a metabolic pathway. Beadle demonstrated that one gene in a fruit fly produces one enzyme which in turn controls a single chemical reaction. In this, each gene acts as a chemical molecule and has a particular function. Beadle and Tatum later confirmed this hypothesis using genetic and biochemical studies of the bread mold Neurospora crassa. Neurospora crassa to prove that in a multistep biochemical pathway, each step is controlled by different enzymes and each of these enzymes is encoded by a specific gene. This is called the one gene-one enzyme hypothesis.

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