One of the major reasons for apoptosis is
The death of cells which occurs as a normal and controlled part of an organism's growth or development is called Apoptosis. It is due to the infection of viruses. It is necessary for the normal development of cells and the cell cycle maturation. It is also important in maintaining the regular functions and activities of cells. It is initiated in the mitochondria and mediated by proteolytic enzymes called caspases
So, the correct option is ‘activity of mitochondria’.