Oogenesis is a complex process regulated by various hormones. Which hormone acts on primary follicles and stimulate its conversion into mature Graafian follicles?
Oogenesis is a type of gametogenesis (formation of gametes) during which a female gamete (ovum) is produced via multiple divisions. The process of gametogenesis is a multistep process that is controlled by the coordinated functions of multiple hormones like Gonadotropin-releasing hormone (GnRH), luteinizing hormone (LH), follicle-stimulating hormone (FSH), etc.
Follicle-stimulating hormone (FSH) is produced from the anterior lobe of the pituitary gland. It is the major hormone stimulated by the production of GnRH from the hypothalamus. It promotes the maturation of primary follicles into Graafian follicles. These follicles then begin to produce estrogen in the form of estradiol. Rising estrogen levels in the blood mainly stimulate the growth of the endometrium and myometrium of the uterus.
Gonadotropin-releasing hormone (GnRH) released from the hypothalamus acts on the anterior pituitary to triggers the production of FSH and LH which helps in follicle maturation and ovulation.
Progesterone is pregnancy maintaining hormone. In general, it inhibits follicular development at concentrations near about 1 μg/ml. High levels of progesterone also have an inhibitory effect on FSH.