Question

What is the difference in amino acid sequence in amino acid sequence in the B - chain of haemoglobin in a normal person and a sickle cell anaemia person?

Answer 1

Sickle cell anaemia is a hereditary blood disorder caused as a result of point mutation. In this disease, Thaimine is replaced with adenine and thus mutation takes place in the amino acid residue, in the beta chain of hemoglobin. Alpha subunit of hemoglobin is normal in persons having this disorder.
In the hemoglobin of a normal person glutamate, the amino acid is present at the 6th position in the beta chain, while in a person having this disease valine is present instead of normal glutamate amino acid