why is the introduction of genetically engineered lymphocytes into an ADA deficient patient not a permanent cure ? suggest a possible permanent and why ?
why is the introduction of genetically engineered lymphocytes into an ADA deficient patient not a permanent cure ? suggest a possible permanent and why ?
ADA (Adenosine deaminase) is an enzyme crucial for immune system. Its deficiency is caused due to the deletion of the gene coding for adenosine deaminase.
The introduction of genetically engineered lymphocytes into an ADA deficient patient is not a permanent cure instead this method requires repeated application.
In case of ADA deficient patients, lymphocytes from their blood are grown in a culture. A functional ADA cDNA (using a retroviral vector) is then introduced into the lymphocytes. These lymphocytes are subsequently returned to the patients. However, as these cells are not immortal, the patient requires periodic infusion. Thus, infusion of genetically engineered lymphocytes is not a permanent cure.
A permanent cure for ADA deficiency is to introduce genes isolated from marrow cells that produce ADA into cells at early embryonic stages.
ADA (Adenosine deaminase) is an enzyme crucial for immune system. Its deficiency is caused due to the deletion of the gene coding for adenosine deaminase.
The introduction of genetically engineered lymphocytes into an ADA deficient patient is not a permanent cure instead this method requires repeated application.
In case of ADA deficient patients, lymphocytes from their blood are grown in a culture. A functional ADA cDNA (using a retroviral vector) is then introduced into the lymphocytes. These lymphocytes are subsequently returned to the patients. However, as these cells are not immortal, the patient requires periodic infusion. Thus, infusion of genetically engineered lymphocytes is not a permanent cure.
A permanent cure for ADA deficiency is to introduce genes isolated from marrow cells that produce ADA into cells at early embryonic stages.
