Question

Phenylketonuria, Huntington's disease and sickle cell anaemia are caused by disorders associated with chromosomes

• A. $7,11$ and $12$
• B. $12,4$ and $11$
• C. $11,4$ and $12$
• D. $7,12$ and $11$
• E. $4,7$ and $11$

Answer 1

Answer: (B)

$12,4$ and $11$

• Classical PKU is an autosomal recessive disorder, caused by mutations in both alleles of the gene for phenylalanine hydroxylase (PAH), found on chromosome 12.
• Huntington's disease is a progressive brain disorder caused by a single defective gene on chromosome 4.
• Sickle cell disease is caused by a mutation in the hemoglobin-Beta gene found on chromosome 11

So, the correct answer is '12,4 and 11'.