Question

Philadelphia chromosome occurs in patients suffering from

• A. Leukemia
• B. Rickets
• C. Hepatitis
• D. Albinism

Answer 1

The correct option is A Leukemia

The Philadelphia (Ph) chromosome is an abbreviated chromosome 22 that was shortchanged in a reciprocal exchange of material with chromosome 9. This translocation occurs in a cell in the bone marrow, and causes chronic myeloid leukemia (CML). It is also found in a form of acute lymphoblastic leukemia. Philadelphia chromosome results in the production of an abnormal enzyme called a tyrosine kinase. Along with other abnormalities, this enzyme causes the cancer cell to grow uncontrollably.

So, the correct answer is 'Leukemia'.