Potential difference across resting membrane is negatively charged. This is due to differential distribution of the following ions.
(a)Na+ and K+ ions (b) CO2−3 and CI− ions
(c) Ca2+ and Mg2+ ions (d) Ca+4 and CI− ions
(a) The ion gated channels on the neurolemma control the movement of Na+ and K+ ions on both inner and outer side of the nerve cell.
Ca2+,CO2−3,Mg2+ and Ca4+ ions are not related with nerve excitation rather are involved in other biological functions Ca+2 ions are related to muscle metabolism where Mg2+ ions act as a cofactor in some reactions.
CI− ion channels are important for setting cell resting membrane potential, transepithelial salt transport, and the acidification of internal and extracellular compartments.