Read the given paragraph and select the option that correctly fills the blanks in it.
Hormones produce their effect on target tissue by binding to specific _________A called hormone receptors located in the target tissues only. Water soluble hormones usually need _________B receptor that generate _________C messengers for regulating cellular metabolism. __________D soluble hormones can pass through cell membrane and bind to _________E receptors, mostly nuclear receptors. The hormone receptors complex enter the nucleus and mostly regulate gene expression or chromosome function by interaction of hormone-receptor complex with the genome.