Question

Regarding the assertion and reason, choose the correct option.
Assertion [A]: Mast cells release excessive amounts of inflammatory chemicals which cause allergic reactions.
Reason [R]: Allergens in the environment on reaching human body stimulate mast cells in certain individuals.

• A. Both assertion and reason are correct and reason is the correct explanation
• B. Both assertion and reason are correct and reason is not the correct explanation
• C. Assertion is correct but reason is wrong
• D. Both assertion and reason are wrong

Answer 1

The correct option is A Both assertion and reason are correct and reason is the correct explanation

Allergic reactions are triggered when allergens cross-link preformed IgE bound to the high-affinity receptors on mast cells. Mast cells line the body surfaces and serve to alert the immune system to local infection. Once activated, they induce inflammatory reactions by secreting chemical mediators stored in preformed granules, and by synthesizing leukotrienes and cytokines after activation occurs. The underlying mechanism involves immunoglobulin E antibodies (IgE), part of the body's immune system, binding to an allergen and then to a receptor on mast cells or basophils where it triggers the release of inflammatory chemicals such as histamines, leading to inflammatory reactions.