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Question

Sickle cell anaemia disorder arises due to

A
duplication of a segment of DNA
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B
substitution of a single base pair of DNA
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C
deletion of a segment of DNA
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D
duplication of a base pair of RNA
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Solution

The correct option is B substitution of a single base pair of DNA
Sicke cell anaemia is an autosomal recessive genetic disorder. In this genetic disorder, valine is synthesized in place of glutamic acid at sixth position of β globin chain of haemoglobin. Due to the change in the structure of haemoglobin, the RBC's become sickle shaped. This genetic disorder is due to substitution of a single base pair of DNA. This type of change in DNA is called point mutation.

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