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Question

Sodium oxalate prevents blood clotting due to

A
Blocking of fibrinogen transformation
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B
Covering RBC
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C
Inhibiting activity of clotting factor of plasma
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D
Combining with calcium ions of blood
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Solution

The correct option is A Combining with calcium ions of blood
Sodium oxalate, like citrates, can be used to remove calcium ions (Ca2+) from blood plasma. It thus prevents blood from clotting. In the presence of calcium ions and other clotting factors, factor X activates an enzyme called prothrombin activator. This enzyme then converts the plasma protein prothrombin into thrombin. Thrombin is an enzyme that, in turn, converts fibrinogen to fibrin.

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