Question

Some of the inhibitors of bacterial protein synthesis and their effect are listed below. Match them and choose the correct option from the answer key.

	List I		List II
A	Chloramphenicol	p	Inhibits binding of aminoacyl tRNA to ribosome
B	Erythromycin	q	Inhibits interaction between tRNA and mRNA
C	Neomycin	r	Inhibits initiation of translation
D	Streptomycin	s	Inhibits peptidyl transferase activity
E	Tetracycline	t	Inhibits translocation of mRNA along ribosomes

• A. A- p, B- q, C- r, D- t, E- s
  
• B. A- r, B- p, C- t, D- s, E- q
  
• C. A- q, B- r, C- s, D- p, E- t
  
• D. A- s, B- t, C- q, D- r, E- p
  
• E. A- t, B- s, C- p, D- q, E- r
  

Answer 1

Answer: (D)

A- s, B- t, C- q, D- r, E- p

Chloramphenicol inhibits peptidyl transferase activity of the bacterial chromosome hence it is used for the treatment of the number of bacterial infections. Erythromycin is also inhibited peptidyl transferase activity as but also inhibits translocation of amino acids during translation. The antibiotic which stops the interaction between tRNA and mRNA is neomycin what it does is inhibits the codon-anticodon interaction from happening, thus killing the bacteria as it cannot process proteins from it's well being. Streptomycin actually is a bacterial ribosome that only inhibits the growth of the bacteria by inducing prokaryotic ribosomes to misread mRNA and thus, inhibit the initiation of translation. And the tetracycline inhibits the binding of aminoacyl tRNA to mRNA ribosomes. Thus, the correct answer is option D.