Question

Suppose you are developing a new drug, and have found that when it is administered in humans, there is a substantial increase in the volume of urine produced. When you administer antidiuretic hormone (ADH or vasopressin) at the same time, the volume of urine returns to normal. Which hypothesis best fits these observations?

• A. Blocks the receptors for ADH on the collecting of the kidney
• B. Blocks the release of ADH from the pituitary
• C. Mimics the action of ADH
• D. Decreases blood pressure

Answer 1

Answer: (B)

Blocks the release of ADH from the pituitary

When a new drug is administered in humans, it increases the urine output. However, when antidiuretic hormone (ADH) is administered at the same time, the urine output is not increasing. Based on this, it can be said the given new drug blocked the release of ADH from the pituitary gland. Due to lack of ADH hormone in the body, the urine output increased substantially. However, when an external dose of ADH was given, the volume of urine returned to normal.

So, the correct answer is 'Blocks the release of ADH from the pituitary.'