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Question

Tay-sachs disease is due to the abnormal

A
Ganglioside
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B
Glycogen
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C
Sphingomyelin
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D
Glycosphingolipid
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Solution

The correct option is A Glycosphingolipid
Tay-sachs disease is a genetic disorder. It is caused due to the mutation in the HEXA genes on chromosome 15. This results from a lack of the enzyme hexosaminidase A and leads to the storage of a fatty acid known as glycosphingolipid in lysosomes. The fatty acid deposition leads to the destruction of nerve cells in the brain and spinal cord. Individuals die at the age 3 or 4.
So, the correct answer is option D.

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