The action potential always moves in one direction because of _____.
Closing of the inactivation gate of Voltage gated Sodium channels
Closing of the inactivation gate of voltage gated Sodium channels. This gate of Voltage gated Sodium channel is not regulated, it closes a while after the channel is open and reopens again after a small period. The activity of this gate ensures that the action potential moves in the forward direction, opening voltage gated channels ahead of the signal and inactivating channels as the signal passes.