The association of histone H1 with a nucleosome indicates:

Transcription is occurring

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DNA replication is occurring

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DNA is condensed into a chromatin fibre

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DNA double helix is exposed

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Solution

The correct option is C DNA is condensed into a chromatin fibre
The negatively charged DNA is wrapped around the positively charged histone octamer to form a nucleosome.

The H1 protein binds to the "linker DNA" region between nucleosomes. This association of H1 with the nucleosome packs the DNA into chromatin fibers.

When replication or transcription is happening, the chromosome needs to decondense and the DNA needs to unwind, so the H1 is removed.

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