The correct option is A Acetylcholine
During the transmission of a nerve impulse across a synapse, the presynaptic membrane is depolarized when it reaches the synaptic knob of the axon, thereby increasing its permeability to Ca+ ions. The entry of Ca+ions from the synaptic cleft to the synaptic knob causes the release of a chemical called neurotransmitter. The common neurotransmitter substance is the acetylcholine.