Question

The coding strand of DNA is :
5'-AATTCAAATTAGG-3'
What is the sequence of mRNA?

• A. 3'-TTAAGTTTAATCC-5'
• B. 5'-AAUUCAAAUUAGG-3'
• C. 3'-AAUUCAAAUUAGG-5'
• D. 5'-TTAAGTTTAATCC-3'

Answer 1

The correct option is B 5'-AAUUCAAAUUAGG-3'

Following the rule of complementarity and Chargaff's rule, the template strand of the DNA would be:
3'-TTAAGTTTAATCC-5'

The mRNA sequence would be complementary to the template strand, following Chargaff's rule, except thymine would be replaced by uracil. Hence:
5'-AAUUCAAAUUAGG-3'