The correct option is C Capturing of Constentinople by Turks
The migration waves of Byzantine scholar and émigrés in the period after the Crusader sacking of Constantinople in 1204 and the end of the Byzantine Empire in 1453, is considered by many scholar keys to the revitalization of Greek and Roman studies that led to the development of the Renaissance humanism and science. These émigrés brought to Western Europe the relatively well-preserved remnants and accumulated knowledge of their own (Greek) civilization, which had mostly not survived the Early Middle Ages in the West. They brought to Western Europe the far greater preserved and accumulated information of their own civilization. According to Britannica: "Many contemporary scholars also agree that the exodus of Greeks to Italy as a result of this event marked the end of the Middle Ages and the beginning of the Renaissance.