1
Question
The first clinical gene therapy was given in 1990 to a 4 years old girl with enzyme deficiency of
The first clinical gene therapy was given in 1990 to a 4 years old girl with enzyme deficiency of
Open in App
Solution
The correct option is C Adenosine deaminase (ADA)
Gene therapy
Gene therapy is the collection of methods in which a defective gene present in the embryo or child is corrected by replacing it with a normal gene to compensate for the malfunctioning of the defective gene.
Adenosine deaminase (ADA)
Adenosine deaminase (ADA) is an enzyme that converts deoxyadenosine to deoxyinosine. ADA enzyme is present in more amounts in lymphocytes where it helps in the recycling of the nucleotides.
First patient to be given gene therapy
● The first patient who was given gene therapy was a 4-year old girl in 1990. She was suffering from Severe Combined ImmunoDeficiency Syndrome caused by a mutation in the gene encoding the enzyme adenosine deaminase (ADA).
● These patients have non-functional lymphocytes and they cannot mount immune responses against invading pathogens. Hence, she was given gene therapy for ADA deficiency.
Final answer:
(a) Adenosine deaminase (ADA)
Gene therapy
Gene therapy is the collection of methods in which a defective gene present in the embryo or child is corrected by replacing it with a normal gene to compensate for the malfunctioning of the defective gene.
Adenosine deaminase (ADA)
Adenosine deaminase (ADA) is an enzyme that converts deoxyadenosine to deoxyinosine. ADA enzyme is present in more amounts in lymphocytes where it helps in the recycling of the nucleotides.
First patient to be given gene therapy
● The first patient who was given gene therapy was a 4-year old girl in 1990. She was suffering from Severe Combined ImmunoDeficiency Syndrome caused by a mutation in the gene encoding the enzyme adenosine deaminase (ADA).
● These patients have non-functional lymphocytes and they cannot mount immune responses against invading pathogens. Hence, she was given gene therapy for ADA deficiency.
Final answer:
(a) Adenosine deaminase (ADA)
Suggest Corrections
1
Similar questions
View More
Join BYJU'S Learning Program
Explore more
Join BYJU'S Learning Program
