Question

The following general structure is representative of sulphonamides. Which of the following statements is true for active sulphonamides?

• A. $R^1$ can be H or an alkyl group
• B. $R^2$ must be hydrogen
• C. The aromatic ring is essential
• D. The sulphonamide functional group can be replaced with an ester

Answer 1

The correct option is C The aromatic ring is essential

Sulfonamide is a functional group( a part of a molecule) that is the basis of several group of drugs, which are called sulphonamides, sulfadrugs or sulpha drugs. The original antibacterial sulfonamides are synthetic(nonantibiiotic) antimicrobial agents that contains the sulfonamide group. Some sulfonamides are also devoid of antibacterial acivity.eg. the anticonvulsant sultiame. The sulfonylureas and thiazide diuretics are new drug group based upon the antibacterial sulfonamides. Allegros to sulfonamide are common. The overall incidence of adverse drug reactions to sulfa antibiotics is approximately 3%, close to penicillin; hence medications containing sulfonamides are prescribed carefully.