Question

The inhibition of an enzyme controlling an early stage of a series of biochemical reactions by the end product, when it reaches a critical concentration is called as

• A. Allosteric inhibition
• B. Feedback inhibiton
• C. Competitive inhibition
• D. Non-competitive inhibition

Answer 1

The correct option is B Feedback inhibiton

Feedback inhibition is a form of allosteric regulation. There is an accumulation of the final product. This product goes and binds to the allosteric site of the enzyme and inhibits its activity. This type of mechanism is observed in the case of hexokinase. The enzyme converts the glucose to glucose-6-phosphate. The enzyme is inhibited by the accumulation of final product glucose-6-phosphate. Hence, when the product reaches the critical concentration, the accumulation of the product causes inhibition of the enzyme which controls the pathway or the first reaction.

Thus, the correct answer is option B.