The net yield of ATP, except substrate-level phosphorylation, from Krebs cycle per glucose molecule is
A
12
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B
24
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C
22
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D
36
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Solution
The correct option is A22 From one molecule of glucose, 38 ATP molecules can be produced during cellular respiration. Glycolysis produces net 2 ATP molecules by substrate level phosphorylation. Kreb cycle produces 2 ATP molecules by substrate level phosphorylation. About 34 ATP are produced from oxidative Phosphorylation. During Kreb cycle, 6 molecules of NAD+ are reduced to NADH and 2 molecules of FAD are reduced to FADH2. Now 6 NADH produce 6 x 3 = 18 ATP molecules. Similarly, 2 FADH2 produce 2 x 2 = 4 ATP molecules. Hence, total 18 + 4 = 22 molecules of ATP are produced per glucose molecule from Kreb cycle except substrate level phosphorylation.