Question

Tumors that affect the pituitary can lead to decreases in some, but not all, hormones released by the pituitary. A patient with such a tumor exhibits fatigue, weight loss, and low blood sugar. This is probably due to lack of production of

• A. GH, which leads to loss of muscle mass.
• B. ACTH, which leads to loss of production of glucocorticoids.
• C. TSH, which leads to loss of production of thyroxin.
• D. ADH, which leads to excess urine production.

Answer 1

The correct option is C TSH, which leads to loss of production of thyroxin.

Thyroid-stimulating hormone (also known as thyrotropin, thyrotropic hormone, TSH, or hTSH for human TSH) is a pituitary hormone that stimulates the thyroid gland to produce thyroxine (T4), and then triiodothyronine (T3) which stimulates the metabolism of almost every tissue in the body. It is a glycoprotein hormone produced by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid.A low TSH and low FT4 or FTI indicates hypothyroidism due to a problem involving the pituitary gland and the symptoms include fatigue, weight loss, and low blood sugar.

So the correct option is 'TSH, which leads to loss of production of thyroxine'.