Question

Ultrastructure of a cell organelle can best be studied through _____________.

• A. Microdissection
• B. Electron microscope
• C. Phase contrast microscope
• D. Autoradiography

Answer 1

The correct option is B Electron microscope

• Microdissection refers to a variety of techniques where a microscope is used to assist in dissection.
• Electron microscopy (EM) is a technique for obtaining high-resolution images of biological and non-biological specimens. It is used in biomedical research to investigate the detailed structure of tissues, cells, organelles, and macromolecular complexes.
• Phase-contrast microscopy is an optical microscopy technique that converts phase shifts in the light passing through a transparent specimen to brightness changes in the image. Phase shifts themselves are invisible but become visible when shown as brightness variations.
• Autoradiography is the bio-analytical technique, used to visualize the distribution of radioactively labeled substances with a radioisotope in a biological sample. It is a method by which radioactive material can be localized within a particular tissue, cell, cell organelles, or even biomolecules.
  Hence the correct answer is (B).