The correct option is D Actual weakened germs or attenuated small pox virus
The smallpox vaccine is the only way to prevent smallpox. The vaccine is made from a virus either weakened or attenuated (has lost its ability to cause the disease), which is introduced into the blood. This helps in building the antibodies against the smallpox virus in the body. Smallpox was eradicated by this vaccination program, starting in 1967.